Physiologically Based Pharmacokinetic Modelling of Serum 25-Hydroxyvitamin D Concentrations in Schoolchildren Receiving Weekly Oral Vitamin D₃ Supplementation.

ABSTRACT: Background: Following vitamin D₃ oral administration, attained serum concentrations of its metabolite 25-hydroxyvitamin D₃ (25(OH)D₃) are variable among children. Methods: We developed physiologically based pharmacokinetic (PBPK) modelling using annually measured serum 25(OH)D₃ concentrations in 77 Cape Town schoolchildren aged 6-11 years who received weekly oral doses of 10,000 IU vitamin D₃ for 3 years during a clinical trial (Δ25(OH)D = 32.2 nmol/L, 95% CI: [-3.2, 65.8] nmol/L). Simulations were performed to test the model on 463 other participants in the same trial, and in a cohort of 1756 Mongolian schoolchildren aged 6-11 years who received weekly oral doses of 14,000 IU vitamin D₃ for 3 years in another

SUBMITTER: Muhamad N 

PROVIDER: S-EPMC12525942 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature