Synthesis and Docking Studies of Glycolipids Inspired by <i>Bacteroides fragilis</i> Lipid A.

ABSTRACT: Bacteroides fragilis, a prominent commensal of the human gut microbiota, plays a vital role in immune system regulation through its capsular polysaccharide A (PSA), which requires a glycolipid anchor structurally reminiscent of lipid A. While canonical Escherichia coli lipid A acts as a potent TLR4 agonist contributing to septic shock and inflammatory disorders, certain B. fragilis-derived glycolipids demonstrate antagonistic effects, offering potential as anti-inflammatory agents. In this study, we report the synthesis and preliminary computational evaluation of a library of glycolipids inspired by B. fragilis lipid A. Three lipid As, including a tetra-acylated 1-phosphoryl lipid A analog (Tetra C-1), were synthesized and assessed using molecular docking simula

SUBMITTER: Kenneth D 

PROVIDER: S-EPMC12525944 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature