Sweet Taste Adaptation to Sugars, Sucralose, and Their Blends: A Human and Rodent Perspective.

ABSTRACT: Background: Sweet taste adaptation, the decline in perceived sweetness with repeated exposure, may influence dietary behavior and differs across sweeteners. Low-calorie sweeteners (LCSs) such as sucralose strongly activate the T1R2+T1R3 receptor and are generally associated with greater adaptation than sugars, although this effect can be reduced with sweetener blends. Aim: We investigated whether habitual LCS consumption affects sweet taste perception and whether blending sucralose with small amounts of sugars attenuates adaptation using sensory tests in humans and in vivo calcium imaging in a rodent model. Methods: In study 1, habitual (HC; n = 39) and non-habitual (NHC; n = 42) LCS consumers rate sweetness of sucralose (0.6 mM), glucose (800 mM), fructo

SUBMITTER: Okoye SI 

PROVIDER: S-EPMC12526075 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature