Postoperative radiotherapy in subtotally resected recurrent WHO grade 1 meningiomas with intermediate-/high-risk molecular profiles.

ABSTRACT:

Background

Meningiomas represent the most common primary intracranial tumors in adults, with World Health Organization (WHO) grade 1 typically associated with favorable outcomes following gross total resection (GTR).

Methods

This retrospective study included patients with CNS WHO grade 1 meningioma and available DNA methylation profiles (n = 210). Clinical tumor characteristics and treatment course (eg, surgical resection, extent of resection, radiotherapy [RT]) were evaluated. Integrated Scores (InS) were calculated based on methylation family using the DKFZ brain tumor classifier, CNS WHO grading, and chromosomal losses, categorized as low, intermediate, or high. Survival analyses employed Kaplan-Meier and Cox regression methods, with local PFS defined as the primary endpo

SUBMITTER: Deng MY 

PROVIDER: S-EPMC12526101 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature