Phytochemical Composition and Acute Hypoglycemic Effect of <i>Jefea lantanifolia</i> (S. Schauer) Strother in Rats.

ABSTRACT: Jefea lantanifolia (S. Schauer) Strother is traditionally used in Hidalgo, Mexico, to manage type 2 diabetes (T2D). The aerial parts are prepared as an infusion and consumed throughout the day. This study conducted a 2 h acute experiment under both fasting and postprandial conditions to evaluate the effects of the aqueous infusion (AE), the ethanol-water extract (EWE), and their isolated constituents in hyperglycemic rats. Structures were established using conventional spectroscopic methods. The absolute configuration was determined by optical rotation and calculated electronic circular dichroism (ECD) methods. Phytochemical analysis led to the isolation of six compounds: luteolin (1); 2β-hydroxy-dimerostemma brasiolide-1-O-(3-hydroxymethacrylate) (2); homoplant

SUBMITTER: Safavi F 

PROVIDER: S-EPMC12526190 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature