Mucin Alterations in Response to High-Fat Diet and the Potential Protective Role of Chickpea Accessions.

ABSTRACT: Background/Objectives: Unhealthy nutrition and lifestyles contribute to the development of chronic diseases such as cardiovascular disease, type 2 diabetes, and colorectal cancer. The Western diet can impair gastrointestinal motility and function. The underlying mechanisms that lead to changes in the mucus barrier and mucin profiles in response to these dietary patterns are still being studied. In mice, dietary fiber intake can improve the intestinal mucosal barrier function, enhance the differentiation process of goblet cells, and increase acidic mucin production. Our study aimed to investigate the effects of a high-fat diet (HFD) on colonic mucin expression and to assess whether chickpea accessions, known for their nutritional benefits, can mitigate these adverse effects. Metho

SUBMITTER: Mentino D 

PROVIDER: S-EPMC12526196 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature