Calcium Oscillations Within Juxtaglomerular Cell Clusters Control Renin Release.

ABSTRACT:

Background

Juxtaglomerular cells are sensors that control blood pressure and fluid-electrolyte homeostasis. They are arranged as clusters at the tip of each afferent arteriole. In response to decreased blood pressure or extracellular fluid volume, juxtaglomerular cells secrete renin, initiating an enzymatic cascade that culminates in the production of Ang II (angiotensin II), a potent vasoconstrictor that restores blood pressure and fluid-electrolyte homeostasis. In turn, Ang II exerts negative feedback on renin release commensurate with increased intracellular Ca²⁺, preventing excessive circulating renin and hypertension. However, within their native structural organization, the intricacies of intracellular Ca²⁺ signaling dynamics and their sources remain unc

SUBMITTER: Yamaguchi H 

PROVIDER: S-EPMC12526284 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature