Triterpene and Caffeoylquinic Acid Constituents Contribute to the Cognitive-Enhancing, but Not Anxiolytic, Effects of a Water Extract of <i>Centella asiatica</i> in Aged Mice.

ABSTRACT:

Background/objectives

A water extract of the plant Centella asiatica (CAW) has been shown to improve cognitive deficits in aged mice when administered for 5 weeks in drinking water. However, the contribution of the constituent compounds within CAW to the beneficial effects of the extract remains unelucidated. This study evaluated the effects of triterpene (TT) and caffeoylquinic acids (CQA) found within CAW, on learning, cognitive flexibility, memory, and anxiety-like behaviors in aged C57BL6 mice.

Methods

Eighteen-month-old male and female C57BL6 mice were administered either TT, CQA, or the combination (TT+CQA) in their drinking water for a total of 5 weeks, at concentrations corresponding to their presence in CAW. During the final two weeks of treatment learning, e

SUBMITTER: Hack W 

PROVIDER: S-EPMC12526379 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature