Cucurbitane Glycosides from <i>Siraitia Grosvenorii</i> and Their Hepatoprotective Activities.

ABSTRACT: Siraitia grosvenorii (S. grosvenorii), a traditional medicine food homology plant, serves both dietary and medicinal purposes and is increasingly exploited for its bioactivities in pharmaceuticals and nutritional value. In this research, fifteen glycosides including three new cucurbitane-type triterpenoid glycosides named Luohanguosides A-C (1-3) and twelve known ones (4-15) have been isolated from the aqueous extract of fresh S. grosvenorii fruits. A comprehensive analysis of 1D, 2D-NMR, HRESIMS techniques along with some other spectroscopic methods led to the elucidation of their chemical structures. Further investigation focused on the hepatoprotective activities of compounds 1-15. It turned out that compounds 1, 5

SUBMITTER: Mao JN 

PROVIDER: S-EPMC12526448 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature