One-Week Elderberry Juice Intervention Promotes Metabolic Flexibility in the Transcriptome of Overweight Adults During a Meal Challenge.

ABSTRACT:

Background

Metabolic flexibility, the ability to efficiently switch between fuel sources in response to changing nutrient availability and energy demands, is recognized as a key determinant of metabolic health. In a recent randomized controlled human feeding trial, overweight individuals receiving American black elderberry juice (EBJ) demonstrated improvements in multiple clinical indices of metabolic flexibility, but the mechanisms of action were unexplored. The objective of this study was to utilize RNA sequencing to examine how EBJ modulates the transcriptional response to fasting and feeding, focusing on pathways related to metabolic flexibility.

Methods

Overweight or obese adults (BMI > 25 kg/m²) without chronic illnesses were randomized to a 5-week crossover

SUBMITTER: Teets C 

PROVIDER: S-EPMC12526507 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature