Polymeric Nanovehicle of α-Tocopheryl Succinate Based on a Methacrylic Derivative of Hydroxychloroquine and Its Cytotoxic Effect on Breast Cancer Cells.

ABSTRACT: This study focuses on the preparation of poly(HCQM-co-VP) copolymeric nanoparticles (NPs) to enhance the aqueous solubility and bioavailability of the hydrophobic and antitumor molecules HCQ (hydroxychloroquine) and α-TOS (α-tocopheryl succinate). HCQ is covalently incorporated into the polymer backbone, while α-TOS is encapsulated within the nanoparticles by non-covalent interactions. Poly(HCQM-co-VP) was synthesized from a vinyl derivative of HCQ (HCQM) and N-vinylpyrrolidone (VP), with a molar composition of 17% HCQM and 83% VP, providing the optimal hydrophobic/hydrophilic balance for forming, via nanoprecipitation, empty nanoparticles (NPs) with a diameter of 123.6 nm and a zeta potential of -5.8 mV. These nanoparticles effectively encapsulated α-TOS within their hydroph

SUBMITTER: Valle H 

PROVIDER: S-EPMC12526677 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature