Comparison of Different Aliphatic Polyester-Based Microparticles as Protein Delivery Systems.

ABSTRACT: The utilization of encapsulated biopharmaceuticals, including peptides and proteins, has grown substantially in recent years. In this study, the influence of aliphatic polyester physicochemical properties, specifically crystallinity and hydrophobicity, on the development of protein-loaded microparticles was investigated. A series of polyesters, namely amorphous PDLLA and semicrystalline PLLA, PCL, and PPDL, were synthesized via chemical and enzymatic ring-opening polymerization. Bovine serum albumin (BSA)-loaded microparticles were fabricated using a water-in-oil-in-water (w/o/w) double emulsion solvent evaporation method. The size of microparticles obtained was determined by scanning electron microscopy and dynamic light scattering methods. The enzymatic degradation o

SUBMITTER: Korzhikov-Vlakh V 

PROVIDER: S-EPMC12526760 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature