Working memory improvements following supramaximal high-intensity interval training predicted by increased prefrontal cortex activation and leg strength gains.

ABSTRACT: Physical exercise shows positive effects on cognitive functions such as working memory (WM) for older adults; however, large individual differences in response exist and the underlying mechanisms are not well understood. We tested the hypothesis that exercise-induced changes in cardiorespiratory fitness and leg strength would improve WM-related brain activity, which subsequently would improve WM performance. This study was based on the Umeå HIT study, a randomized controlled trial assessing the effects of watt-controlled supramaximal high-intensity interval training (HIT) versus moderate-intensity training for nonexercising older adults (N = 68). A subsample (n = 43, 66 to 79 years, 56% females) underwent task-based functional magnetic resonance imaging, testing WM. The outcomes of interes

SUBMITTER: Sandstrom S 

PROVIDER: S-EPMC12526879 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature