Pneumococcal Serotype Distribution and Coverage of Existing and Pipeline Pneumococcal Vaccines.

ABSTRACT:

Background

Next-generation pneumococcal conjugate vaccines (PCVs) target an expanding array of serotype antigens. We assessed the proportions of invasive pneumococcal disease (IPD) and pneumococcal acute respiratory infections (ARIs) caused by serotypes targeted by existing and pipeline PCVs, and the annual United States pneumococcal disease burdens potentially preventable by these products.

Methods

We estimated serotype distribution and proportions of pneumococcal ARIs (acute otitis media [AOM; children only], sinusitis, nonbacteremic pneumonia) and IPD attributable to serotypes targeted by each PCV using Markov chain Monte Carlo approaches incorporating data from epidemiological studies and Active Bacterial Core surveillance. We then estimated annual numbers of outpatient-

SUBMITTER: King LM 

PROVIDER: S-EPMC12526911 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature