C-Myc Inhibits Macrophage Antimycobacterial Response in Mycobacterium tuberculosis Infection.

ABSTRACT:

Background

Mycobacterium tuberculosis (MTB) remains a major cause of global mortality, yet natural immunity prevents disease in more than 90% of exposed individuals. Interferon gamma (IFN-γ) is a critical regulator of innate immunity and enhances macrophage antimicrobial responses.

Methods

Using in vitro systems approaches, we compared the effects of IFN-γ exposure before versus after infection. We manipulated c-Myc in primary macrophages with a tetracycline-inducible lentiviral system. c-Myc expression was also analyzed in tissues from murine tuberculosis models and human granulomas.

Results

Preinfection IFN-γ exposure primed macrophages for enhanced bacterial control, whereas postinfection exposure did not. We identified c-Myc signaling as a central determinant of m

SUBMITTER: Sarti E 

PROVIDER: S-EPMC12526935 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature