Effects of romosozumab and teriparatide on hip bone using 3D-SHAPER in postmenopausal women with osteoporosis.

ABSTRACT: DXA-based 3D-modeling (3D-DXA) of the hip was used to assess estimated changes in bone integral, cortical, and trabecular parameters and analyze 3D anatomical distribution of changes in bone parameters over time in women who transitioned to romosozumab or teriparatide following treatment with oral bisphosphonates in STRUCTURE and in treatment-naïve women in a romosozumab phase 2 dose-ranging study (Phase 2 study). Data from women who had hip DXA scans at baseline and months 6 and 12 in STRUCTURE or baseline and months 3, 6, and 12 in the Phase 2 study and provided consent for future research were analyzed. 3D-SHAPER software was applied to generate patient-specific 3D-models from hip DXA scans. Percentage changes from baseline in areal BMD (aBMD), integral volumetric BMD (vBMD), cortical t

SUBMITTER: Lewiecki EM 

PROVIDER: S-EPMC12526953 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature