Personalized pulse wave propagation modeling to improve vasopressor dosing management in patients with severe traumatic brain injury.

ABSTRACT: This study investigates whether examining the shape of arterial pulse waves and fitting to them a physiology-based mathematical model of pulse wave propagation can provide additional insights into the state of the cardiovascular system in patients with severe traumatic brain injury (sTBI), potentially enhancing vasopressor dosing strategies. We conducted a longitudinal study on 25 sTBI patients in an intensive care unit. Arterial pulse waves were recorded non-invasively from wrists and ankles using an oscillometric method and were used to inform a 0-1D model of the arterial blood flow dynamics. Model-estimated, patient-specific cardiovascular parameters were then used in a statistical model to predict changes in the administered dose of vasopressor (norepinephrine) in the next 24 hours. The

SUBMITTER: Wolos K 

PROVIDER: S-EPMC12527194 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature