Current and future burden of gynecological cancers attributable to high body-mass index: A comprehensive global analysis and projection study.

ABSTRACT:

Background

High body-mass index (BMI) is a major modifiable risk factor for gynecological cancers, yet its contribution to the global cancer burden remains incompletely characterized. This study provides a comprehensive analysis of the current burden of gynecological cancers attributable to high BMI and projects future trends through 2050.

Methods

We analyzed data from the Global Burden of Disease (GBD) 2021 study, examining uterine and ovarian cancers attributable to high BMI across 204 countries and territories. Burden was quantified using deaths and disability-adjusted life years (DALYs). Temporal trends were identified using joinpoint regression analysis, while future burden was projected using Bayesian Age-Period-Cohort (BAPC) models. We evaluated relationships between

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12527201 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature