Metabolite dynamics over the course of anti-tuberculosis treatment in individuals with mild and severe tuberculosis.

ABSTRACT: Mycobacterium tuberculosis (Mtb) manipulates host metabolism to gain nutrients and increase virulence. Despite known alterations in metabolism in individuals with pulmonary tuberculosis (PTB) during anti-tuberculosis (TB) treatment, the effect of disease severity on metabolite dynamics in individuals with PTB remains understudied. We examined metabolite dynamics over the course of anti-TB treatment in individuals diagnosed with mild (N = 8; smear grade of 1 + /2+ and mild chest x-ray (CXR) abnormality) or severe drug-sensitive PTB (N = 8; 3 + smear grade and moderate/advanced CXR abnormality) in a pilot proof-of-concept study compared to controls without TB (N = 7). Semi-targeted metabolomic analysis of plasma was performed using tandem liquid chromatography-mass spectrometry and electrosp

SUBMITTER: Kagemann CH 

PROVIDER: S-EPMC12527214 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature