Estimating the undetected burden and the likelihood of strain persistence of drug-resistant Neisseria gonorrhoeae.

ABSTRACT: Neisseria gonorrhoeae has developed resistance to all antibiotics recommended for treatment, and reports of reduced susceptibility to ceftriaxone, the last-line treatment, are increasing. Because many asymptomatic infections remain undiagnosed and most diagnosed infections do not undergo antibiotic susceptibility testing, surveillance systems may underestimate resistant infections. In this modeling study, we simulated the spread of a new strain of ceftriaxone-nonsusceptible N. gonorrhoeae in a population comprising men who have sex with men as well as heterosexual men and women. We compared scenarios with varying strain characteristics and surveillance capacity. For each scenario, we estimated 1) the number of undetected infections of the novel strain and 2) the likelihood of strain persis

SUBMITTER: Oliveira Roster KI 

PROVIDER: S-EPMC12527230 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature