Understanding lipidomics associations and the lipoprotein-related caveats in population epidemiology.

ABSTRACT: Mass spectrometry lipidomics is becoming customary to analyze serum/plasma samples in epidemiology. The measurables are molecular constituents of lipoprotein particles, but very little is known about the consequences of adjusting lipidomics data with lipoprotein measures. We studied 2 population cohorts with 5657 and 2036 participants. Liquid chromatography/tandem mass spectrometry lipidomics was applied to analyze 24 molecular lipid classes and nuclear magnetic resonance spectroscopy to quantify 7 lipoprotein lipids plus apolipoprotein A-I and B. The associations of these measures were analyzed via partial Spearman's correlations. The effects of 9 different lipoprotein adjustments on these interrelationships were assessed. Multivariable regression modeling with these adjustments was also

SUBMITTER: Zhao S 

PROVIDER: S-EPMC12527231 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature