The nuclear transport factor IPO5 revealed as a critical mediator of male germline development†.

ABSTRACT: The highly conserved nuclear transport protein importin 5 (IPO5) binds cargo implicated in fundamental processes including virus and chromatin assembly, germline development, and cell signaling. It also anchors cell-specific cargo for functional outcomes in development and immune responses. IPO5 displays both spatial and temporal regulation in the male germline, from fetal through to adult ages. Because it transports key early developmental/reproductive factors, including Stella and the BMP signaling SMADs 1/5/9, we hypothesized that targeted IPO5 deletion would impair germline development and viability at specific stages. Here, we demonstrate in vivo functional importance of IPO5 by generating global and conditional IPO5 knockout mice using an Ipo5FL/FL allele flanking exons 9 and 10. Glo

SUBMITTER: Young JC 

PROVIDER: S-EPMC12527242 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature