Integrative genetic analysis reveals new relationships between intraocular pressure, glaucoma, and ischemic stroke risk: a study based on combined SNP-to-gene, Mendelian randomization and pathway investigations.

ABSTRACT: Ischemic stroke (IS) is a leading cause of death in elderly people. Previous studies exploring the association between intraocular pressure (IOP), glaucoma, and IS have provided inconsistent results. Here, we aimed to clarify this causal relationship, as a better understanding may reveal novel therapeutic targets and preventive strategies. We performed a bidirectional Mendelian randomization (MR) study to explore the causal relationship between IOP, glaucoma, and IS. Complementary studies such as MR-Egger regression, MR-PRESSO, and MRlap were conducted to assess the robustness of the causal associations. Next, the single nucleotide polymorphisms (SNPs) selected as instrumental variables for IOP and primary open-angle glaucoma (POAG) were mapped to relevant genes by the novel combined SNP-t

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC12527246 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature