Urinary extracellular vesicle RNAs as novel <b>biomarkers</b> for diagnosis and prognosis of lupus nephritis.

ABSTRACT:

Background

Lupus nephritis (LN) is among the most serious organ manifestations of systemic lupus erythematosus (SLE), contributing significantly to morbidity and long-term renal outcomes. The development of noninvasive biomarkers capable of distinguishing active LN from non-renal SLE is of considerable clinical importance. Although renal biopsy remains the diagnostic gold standard, its invasive nature limits its utility for serial monitoring. In recent years, urine has emerged as a promising noninvasive medium for detecting renal inflammation and assessing disease activity.

Methods

This study investigated whether RNA signatures within urinary extracellular vesicles (EVs) could serve as diagnostic biomarkers for LN. Urinary EVs were isolated from 27 patients with active LN an

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12527279 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature