Indocyanine green versus technetium-99m for sentinel lymph node biopsy in breast cancer: the FLUORO trial.

ABSTRACT:

Background

Standard sentinel lymph node (SLN) mapping for early breast cancer involves technetium-99m (99mTc) lymphoscintigraphy. Indocyanine green (ICG) fluorescence allows real-time visualization of lymphatics and nodes while avoiding radiation exposure and the inconvenience of 99mTc, but its inclusion in international guidelines is not widespread. This study compared efficacy and costs between ICG and 99mTc for axillary SLN lymphatic mapping.

Methods

Patients with early breast cancer and clinically negative axilla who underwent lymphatic mapping with ICG and 99mTc were enrolled in a prospective single-institution single-arm non-randomized trial (2021-2024). Data on the number of SLNs, including metastatic nodes, rate of failed mapping, costs, and the surgeon's reported ea

SUBMITTER: Nguyen CL 

PROVIDER: S-EPMC12527340 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature