Lymph node ratio predicts adjuvant chemotherapy benefit in esophageal squamous cell carcinoma.

ABSTRACT:

Background

The lymph node ratio (LNR) has emerged as an important prognostic factor in various cancers, including esophageal squamous cell carcinoma (ESCC). This study aimed to evaluate the utility of LNR in guiding decisions for adjuvant chemotherapy in ESCC patients following resection.

Materials and methods

A retrospective analysis was conducted on 2267 patients who underwent potentially curative surgery for ESCC at Sichuan Cancer Hospital and Institute between January 2010 and December 2017. Univariate and multivariate Cox proportional hazards regressions were used to assess factors influencing overall survival (OS), with LNR analyzed using restricted cubic splines (RCS) to explore its relationship with treatment and survival outcomes. Propensity score matching (PSM) was

SUBMITTER: Peng J 

PROVIDER: S-EPMC12527439 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature