Locoregional Therapies for Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.

ABSTRACT:

Importance

Several locoregional therapies (LRTs) for nonmetastatic hepatocellular carcinoma (HCC) are available; however, a global comparison of the relative efficacy of each is needed.

Objective

To conduct a systematic review and direct, pairwise meta-analytic comparison of all identified randomized clinical trials evaluating the treatment of nonmetastatic HCC.

Data sources

A comprehensive search of PubMed and the proceedings of the American Society of Clinical Oncology and American Society for Radiation Oncology annual meetings from January 1, 2010, to November 1, 2023, was performed.

Study selection

Randomized clinical trials using a form of LRT (surgery with or without adjuvant therapy, radiofrequency ablation [RFA], microwave ablation [MWA], radiotherapy [

SUBMITTER: Patel KR 

PROVIDER: S-EPMC12527482 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature