Normative amygdala fMRI response during emotional processing as a trait of depressive symptoms in the UK Biobank.

ABSTRACT:

Background

Heightened reactivity in the amygdala measured by functional magnetic resonance imaging during emotional processing is considered a potential biomarker for clinical depression. Still, it is unknown whether this is also true for depressive symptoms in the general population, and - when in remission after recurrent depressive episodes - it is associated with future episodes.

Methods

Using the UK Biobank population study (n = 11,334), we investigated the association of amygdala reactivity during negative facial stimuli, focusing on lifetime depression (trait), depressive symptoms (state), and the modulating effect of antidepressant (AD) treatment thereof. We employed normative modeling (NM) to better incorporate population heterogeneity of the amygdala activit

SUBMITTER: van den Berg JJ 

PROVIDER: S-EPMC12527494 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature