Cognitive trajectories and dementia risk in patients with schizophrenia spectrum versus affective disorders.

ABSTRACT:

Background

Schizophrenia spectrum disorders confer an increased and earlier dementia diagnosis risk, but the relative timing and course of cognitive decline compared to individuals with affective disorders is unclear.

Methods

This retrospective study used de-identified electronic patient records to compare cognitive trajectories from the first recorded MMSE, representing the earliest cognitive concerns in relation to a possible dementia syndrome, and subsequent dementia risk between patients with a schizophrenia spectrum and primary affective disorder diagnosis. Patients had at least two MMSE scores recorded at least 6 months apart. We examined annual MMSE change from the first recorded MMSE, dementia risk, dementia subtypes, and rates of dementia assessment and treatment.

SUBMITTER: Liu KY 

PROVIDER: S-EPMC12527496 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature