Network-dependent cortical thickness reductions following chronic methamphetamine use.

ABSTRACT:

Background

Cortical thickness reductions associated with chronic methamphetamine use exhibit a non-uniform spatial distribution across brain regions. A potential neurobiological mechanism underlying for this heterogeneous pattern may involve the structural and functional organization of cortical connectivity networks, which could mediate the propagation of neuroanatomical alterations. Here, we aimed to explore how brain network architecture constrains cortical thickness alterations and their clinical relevance.

Methods

The 3D-T1 images were acquired from 139 patients with methamphetamine use disorder (MUD) and 119 sex- and age-matched healthy controls. We first characterized distributed cortical thinning patterns in patients with MUD, then evaluated the relationships between

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12527499 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature