The effects of rTMS on self-reported quality of life in younger and older adults with major depressive disorder.

ABSTRACT:

Background

Repetitive transcranial magnetic stimulation (rTMS) is a well-established intervention for treatment-resistant depression. However, its effects on patient-reported outcomes, such as quality of life (QoL), have not been fully characterized, especially among older adults. This study compares the impact of rTMS on QoL in younger (<60 years) versus older (≥60 years) adults with major depressive disorder.

Methods

We analyzed data from 531 participants with depression (ages 18-89 years) from two randomized clinical trials (THREE-D and FOUR-D). All participants received either unilateral or bilateral rTMS or theta burst stimulation. QoL was assessed using the Quality of Life Enjoyment and Satisfaction Questionnaire - Short Form at baseline, end of treatment, and 12-week

SUBMITTER: Goke K 

PROVIDER: S-EPMC12527504 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature