Network localization of genetic risk for schizophrenia and bipolar disorder.

ABSTRACT:

Background

There is a considerable overlap in clinical features and genetics between schizophrenia (SZ) and bipolar disorder (BD). Previous neuroimaging research has demonstrated common and distinct brain damage patterns between relatives (RELs) of SZ and BD patients, suggesting shared and differential genetic influences on the brain. Despite an increasing recognition that disorders localize better to distributed brain networks than individual brain regions, studies investigating network localization of genetic risk for SZ and BD are still lacking.

Methods

To address this gap, we initially identified brain functional and structural damage locations in SZ- and BD-RELs from 103 published studies with 2364 SZ-RELs, 864 BD-RELs, and 4114 healthy controls. By applying novel funct

SUBMITTER: Yao S 

PROVIDER: S-EPMC12527508 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature