Exploring graphical approaches to assess the impact of an additional trial on a decision model via updated meta-analysis.

ABSTRACT: Graphical displays are often utilised for high-quality reporting of meta-analyses. Previous work has presented augmentations to funnel plots that assess the impact that an additional trial would have on an existing meta-analysis. However, decision-makers, such as the National Institute for Health and Care Excellence in the United Kingdom, assess health technologies based on their cost-effectiveness, as opposed to efficacy alone. Motivated by this fact, this article outlines a novel approach, developed for augmenting funnel plots, based on the ability of an additional trial to change a decision regarding the optimal intervention. The approach is presented for a generalised class of economic decision models, where the clinical effectiveness of the health technology of interest is informed by

SUBMITTER: Robinson W 

PROVIDER: S-EPMC12527514 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature