Behavioral and neural dysfunctions in reward-related cognitive control among adolescents with major depressive disorder.

ABSTRACT:

Background

Reward can influence cognitive control; however, dysfunctional interactions between reward and cognitive control in adolescents with major depressive disorder (MDD) remain unclear.

Methods

We recruited 35 adolescents with MDD and 29 healthy controls (HC) who completed the AX version of the Continuous Performance Test (AX-CPT) under reward and non-reward conditions, while undergoing functional Near-Infrared Spectroscopy (fNIRS).

Results

Adolescents with MDD exhibited slower response times and higher error rates compared to healthy controls. Under reward conditions, they responded more quickly but made more errors. Hierarchical Drift Diffusion Modeling (HDDM) revealed that adolescents with MDD showed a reduced starting bias toward more rewarding responses and

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC12527516 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature