Alterations of structural-functional connectivity coupling in older adults with depressive symptoms.

ABSTRACT:

Background

Prior research indicates that both structural and functional networks are compromised in older adults experiencing depressive symptoms. However, the potential impact of abnormal interactions between brain structure and function remains unclear. This study investigates alterations in structural-functional connectivity coupling (SFC) among older adults with depressive symptoms, and explores how these changes differ depending on the presence of physiological comorbidities.

Methods

We used multimodal neuroimaging data (dMRI/rs-fMRI) from 415 older adults with depressive symptoms and 415 age-matched normal controls. Subgroups were established within the depressive group based on the presence of hypertension, hyperlipidemia, diabetes, cerebrovascular disease, and sleep

SUBMITTER: Li T 

PROVIDER: S-EPMC12527525 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature