The relationship between recreational cannabis use, psychotic-like experiences, and the salience network in adolescent and young adult twins.

ABSTRACT:

Background

The use of cannabis in adolescence and early adulthood, critical phases for brain development, is linked to psychotic-like experiences (PLEs). The underlying mechanisms, however, remain unclear. This research examined the relationship between recreational cannabis use and PLEs, emphasizing the connectivity of the salience network (SN), which plays a role in salience processing and psychosis. To determine whether this relationship reflects shared genetic or environmental contributions, twin modeling was used.

Methods

We included 232 healthy adolescent Turkish twins who underwent diffusion MRI and psychometric assessment. SN connectivity was quantified using graph theory metrics. Linear mixed models were used to examine the associations among cannabis use, SN factor

SUBMITTER: Atmaca-Turan H 

PROVIDER: S-EPMC12527529 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature