Sensitivity analysis for reporting bias on the time-dependent summary receiver operating characteristics curve in meta-analysis of prognosis studies with time-to-event outcomes.

ABSTRACT: In prognosis studies with time-to-event outcomes, the survivals of groups with high/low biomarker expression are often estimated by the Kaplan-Meier method, and the difference between groups is measured by the hazard ratios (HRs). Since the high/low expressions are usually determined by study-specific cutoff values, synthesizing only HRs for summarizing the prognostic capacity of a biomarker brings heterogeneity in the meta-analysis. The time-dependent summary receiver operating characteristics (SROC) curve was proposed as a cutoff-free summary of the prognostic capacity, extended from the SROC curve in meta-analysis of diagnostic studies. However, estimates of the time-dependent SROC curve may be threatened by reporting bias in that studies with significant outcomes, such as HRs, are more

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12527534 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature