Previous Antiplatelet Therapy on Ticagrelor-Aspirin and Clopidogrel-Aspirin Efficacy in Intracranial Artery Stenosis.

ABSTRACT:

Background and purpose

This study aims to investigate the effects of previous antiplatelet therapy on the efficacy and safety of ticagrelor-aspirin versus clopidogrel-aspirin among patients with and without intracranial artery stenosis (ICAS) using data from the Ticagrelor or Clopidogrel with Aspirin in High-Risk Patients with Acute Nondisabling Cerebrovascular Events-II (CHANCE-2) trial.

Methods

In this post-hoc analysis of the CHANCE-2 trial, patients who underwent intracranial artery imaging were included. The primary efficacy and safety outcomes were recurrent stroke and severe or moderate bleeding within 90 days.

Results

Among the 5,920 patients included, the median age was 64.8 years (interquartile range, 57.0-71.4), 2,004 (33.9%) were females, 2,385 (40.3%) had

SUBMITTER: Xu Q 

PROVIDER: S-EPMC12527583 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature