CYBC1 Drives Glioblastoma Progression via Reactive Oxygen Species and NF-κB Pathways.

ABSTRACT:

Purpose

This study aims to investigate the role of cytochrome b-245 chaperone 1 (CYBC1) in glioblastoma (GBM) progression, focusing on its involvement in reactive oxygen species (ROS) production and associated signaling pathways. Understanding the molecular mechanisms driven by CYBC1 could provide new therapeutic targets and prognostic markers for GBM.

Materials and methods

Publicly available datasets were analyzed to assess CYBC1 expression in GBM and its correlation with patient survival. GBM cell lines were genetically manipulated using the CRISPR/Cas9 system to deplete CYBC1. The effects of CYBC1 deficiency on cell proliferation, migration, invasion, and cell cycle dynamics were experimentally evaluated. Additionally, the impact of CYBC1 on the expression of NOXA1, a sub

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC12527619 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature