Clinical Characteristics of and Treatment Pattern for EGFR-Amplified Colorectal Cancer.

ABSTRACT:

Purpose

This study aimed to compare clinicopathologic features and clinical outcomes of metastatic colorectal cancer (mCRC) based on epidermal growth factor receptor (EGFR) amplification status.

Materials and methods

Patients with mCRC who underwent next-generation sequencing using a targeted 244-gene panel from 2016 to 2021 were identified and screened for EGFR copy numbers. Cases with at least five copies were reviewed for tumor purity adjustment, and those with an adjusted copy number of ≥ 6 were defined as EGFR-amplified (EGFR amp+). Their clinical characteristics were compared with those without EGFR amplification (EGFR amp-).

Results

Among 2,421 patients, 35 (1.4%) were EGFR amp+. Clinical characteristics did not significantly differ according to EGFR amplificat

SUBMITTER: Kim SE 

PROVIDER: S-EPMC12527622 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature