Novel Breast Cancer Risk Assessment Tools for Pre- and Postmenopausal Asian Women: Development and Validation in a Nationwide Mammographic Screening Cohort.

ABSTRACT:

Purpose

Widely used breast cancer risk-prediction tools are based on data from Western countries, but risk factors may differ for Asian women. Hence, we aimed to develop a risk assessment tool for breast cancer in Asian women using a nationwide, population-based mammographic screening cohort.

Materials and methods

Women aged ≥ 40 years who underwent breast cancer screening and general health examination in 2009 were included. Age, body mass index (BMI), breast density, lifestyle and reproductive factors, and comorbidities were used to develop 5-year breast cancer risk-prediction models for premenopausal (n=771,856) and postmenopausal (n=1,108,047) women at baseline. The best-fit risk prediction model was constructed using backward stepwise selection in a Cox proportional haz

SUBMITTER: Jung W 

PROVIDER: S-EPMC12527624 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature