B Cell Activating Factor Does Not Play a Pivotal Role in the Synthesis of Aberrantly Glycosylated IgA.

ABSTRACT:

Aim

IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide, yet its pathogenesis remains incompletely understood. B cell activating factor (BAFF), a TNF family member involved in B cell activation and IgA class switching, has been proposed as a potential pathogenic factor in IgAN. However, its role in disease progression is unclear. This study aimed to investigate the pathological role of BAFF in IgAN using grouped ddY (gddY) mice, a spontaneous murine model of IgAN.

Methods

gddY mice were treated with anti-BAFF monoclonal antibody (anti-BAFF Ab) or PBS via intraperitoneal injection twice a week for 4 weeks. Urinary albumin, serum immunoglobulins, and IgA-IgG immune complex were measured pre- and post-treatment. Serum levels of aberrantly glycosylated

SUBMITTER: Kim JS 

PROVIDER: S-EPMC12527645 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature