Integrative Analysis of Mitochondrial-Related Genes Reveals Diagnostic Biomarkers and Therapeutic Targets in Acute Pancreatitis.

ABSTRACT: Mitochondrial dysfunction is increasingly recognised as a critical contributor to acinar cell injury and systemic inflammation in acute pancreatitis (AP). However, comprehensive screening of mitochondrial-related genes (MRGs) and their mechanistic roles in AP progression remains limited. We integrated transcriptomic data with MRGs from the MitoCarta database. A total of 34 differentially expressed MRGs were identified, enabling classification of AP samples into three molecular subtypes with distinct immune cell infiltration patterns and clinical severity. Three hub genes were consistently identified by three machine learning algorithms: LASSO, SVM-RFE, and RF. qRT-PCR validation in cellular models confirmed consistent expression trends. Multi-level functional annotation was conducted throu

SUBMITTER: Lin Y 

PROVIDER: S-EPMC12527819 | biostudies-literature | 2025 Jan-Dec

REPOSITORIES: biostudies-literature