Temporal trends in malignancy incidence and outcomes among kidney transplantation recipients: a multi-center real-world evidence study using the TriNetX network (2000-2010 vs. 2010-2021).

ABSTRACT:

Abbreviations

BMI, body mass index; CI, confidence interval; ESRD, end stage renal disease; HR, hazard ratio; IRB, Institutional Review Board; ICD, International Classification of Diseases; KTX, kidney transplantation; mTOR, mammalian target of rapamycin; PSM, propensity scoring matching; PTM: post-transplantation malignancy; SIR, standardized incidence ratio; SMR, standardized mortality rate.

Objective

Malignancy is a main cause of mortality and morbidity in kidney transplantation recipients. Advancements in cancer surveillance and treatment may contribute to increased incidence and improved clinical outcomes. This study aimed to investigate the trends and clinical outcomes of post-transplantation malignancies over the past two decades.

Methods

We conducted a retrosp

SUBMITTER: Lai GS 

PROVIDER: S-EPMC12527844 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature