Clinical association and potential molecular mechanisms of neonatal sepsis and necrotizing enterocolitis.

ABSTRACT:

Background

Necrotizing enterocolitis (NEC) is a severe intestinal disease affecting premature infants, with mortality rates of 20%-30%. Clinical studies have shown that neonatal sepsis (NS) is an independent risk factor for NEC; however, the shared molecular mechanisms and diagnostic biomarkers between these two conditions remain poorly understood. This study aims to explore the shared molecular mechanisms underlying the association between NS and NEC and to identify potential diagnostic biomarkers.

Methods

This study combines clinical cohort analysis with transcriptomic analysis. First, we enrolled 74 NEC infants and 74 gestational age/birth weight-matched controls from Children's Hospital of Soochow University and quantified the association between NS and NEC using logisti

SUBMITTER: Liu X 

PROVIDER: S-EPMC12527884 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature