Effects of probiotic supplementation on islet β-cell function in subjects with glucose metabolism disorders: a meta-analysis.

ABSTRACT:

Background

Islet β-cell dysfunction is central to the pathophysiology of glucose metabolism disorders. Probiotic supplementation has been shown to benefit glycemic control, but existing evidence on β-cell function remains inconclusive. This meta-analysis investigated the effects of probiotic supplementation on pancreatic islet β-cell function, as assessed by the homeostasis model assessment for β-cell function (HOMA-β), in individuals with impaired glucose metabolism.

Methods

A systematic search of PubMed, Embase, Web of Science, and the Cochrane Library was conducted. We included randomized controlled trials (RCTs) comparing probiotics with placebo or no additional treatment in adults with abnormal glucose metabolism. Random-effects meta-analysis was performed, accounting f

SUBMITTER: Xiang M 

PROVIDER: S-EPMC12527896 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature