Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells.

ABSTRACT: Acquisition of specific cell shapes and morphologies is a central component of cell fate transitions. Although signalling circuits and gene regulatory networks that regulate pluripotent stem cell differentiation have been intensely studied, how these networks are integrated in space and time with morphological changes and mechanical deformations to control state transitions remains a fundamental open question. Here we focus on two distinct models of pluripotency, preimplantation inner cell mass cells of human embryos and primed pluripotent stem cells, to discover that cell fate transitions associate with rapid, compaction-triggered changes in nuclear shape and volume. These phenotypical changes and the associated active deformation of the nuclear envelope arise from growth factor signallin

SUBMITTER: McCreery KP 

PROVIDER: S-EPMC12527910 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature