Parent-of-origin effects on complex traits in up to 236,781 individuals.

ABSTRACT: Parent-of-origin effects (POEs) occur when the effect of a genetic variant depends on its parental origin¹. Traditionally linked to genomic imprinting, POEs are believed to occur due to parental conflict over resource allocation to offspring, resulting in opposing parental influences². Despite their importance, POEs remain underexplored in complex traits, owing to the lack of parental genomes. Here we present an approach to infer the parent of origin of alleles without parental genomes, leveraging interchromosomal phasing, mitochondrial and X chromosome data, and sex-specific crossover in siblings. Applied to the UK Biobank, this enabled parent-of-origin inference for up to 109,385 individuals. Genome-wide association study scans for 59 complex traits and over 14,000

SUBMITTER: Hofmeister RJ 

PROVIDER: S-EPMC12527933 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature