Network synchrony creates neural filters promoting quiescence in Drosophila.

ABSTRACT: Animals require undisturbed periods of rest during which they undergo recuperative processes¹. However, it is unclear how brain states arise that are able to dissociate an animal from its external world, enabling quiescent behaviours, while retaining vigilance to salient sensory cues². Here we describe a neural mechanism in Drosophila that creates neural filters that engender a brain state that enables quiescent behaviour by generating coherent slow-wave activity (SWA)³ between sleep-need⁴ (R5)- and locomotion-promoting neural networks⁵. The coherence of SWA is subject to circadian and homeostatic control and can be modulated by sensory experience. Mimicry of coherent SWA reveals that R5 oscillations reduce responsiveness to visual sti

SUBMITTER: Raccuglia D 

PROVIDER: S-EPMC12527942 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature