Divergent evolutionary strategies pre-empt tissue collision in gastrulation.

ABSTRACT: Metazoan development proceeds through a series of morphogenetic events that sculpt body plans and organ structures^1,2. In the early embryo, these processes occur concurrently such that forces generated in neighbouring tissues can impose mechanical stresses on each other^3-5, potentially disrupting development and consequently decreasing fitness. How organisms evolved mechanisms to mitigate inter-tissue mechanical conflicts remains unclear. Here, we combined phylogenetic survey, quantitative live imaging and functional mechanical perturbation to investigate mechanical stress management during gastrulation across the insect order of flies (Diptera). We identify two distinct cellular mechanisms that prevent tissue collision between the expanding head and trunk. In Cyclorr

SUBMITTER: Dey B 

PROVIDER: S-EPMC12527943 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature